Listar por autor "Garmendia García, Juncal"
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Adaptación molecular de la interacción del patógeno bacteriano Haemophilus Influenzae con el sistema respiratorio humano
Haemophilus influenzae no tipificable (HiNT) es una bacteria Gram-negativa que forma parte de la microbiota de la nasofaringe de individuos con función pulmonar normal. En patologías respiratorias como es el caso ... -
Antagonistic pleiotropy in the bifunctional surface protein fadl (OmpP1) during adaptation of Haemophilus influenzae to chronic lung infection associated with chronic obstructive pulmonary disease
Moleres Apilluelo, Javier ; Fernández Calvet, Ariadna ; Ehrlich, Rachel L.; Martí, Sara; Pérez Regidor, Lucía; Euba, Begoña; Rodríguez Arce, Irene ; Balashov, Sergey; Cuevas, Ester; Liñares, Josefina; Ardanuy, Carmen; Martín Santamaría, Sonsoles; Ehrlich, Garth D.; Mell, Joshua Chang; Garmendia García, Juncal (American Society for Microbiology, 2018) Artículo / ArtikuluaTracking bacterial evolution during chronic infection provides insights into how host selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen nontypeable Haemophilus influenzae (NTHi) infects ... -
Apoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
Martínez, Isidoro; Oliveros, Juan C.; Cuesta, Isabel; Barrera, Jorge de la; Ausina, Vicente; Casals, Cristina; Lorenzo, Alba de; García, Ernesto; García Fojeda, Belén; Garmendia García, Juncal; González Nicolau, Mar; Lacoma, Alicia; Menéndez, Margarita; Moranta, David; Nieto, Amelia; Ortín, Juan; Pérez González, Alicia; Prat, Cristina; Ramos Sevillano, Elisa; Regueiro, Verónica; Rodríguez Frandsen, Ariel; Solís, Dolores; Yuste, José E.; Bengoechea Alonso, José Antonio; Melero, José A. (Frontiers Media, 2017) Artículo / ArtikuluaLower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by ... -
Characterization of nontypable haemophilus influenzae isolates recovered from adult patients with underlying chronic lung disease reveals genotypic and phenotypic traits associated with persistent infection
Garmendia García, Juncal; Viadas Martínez, Cristina ; Calatayud, Laura; Mell, Joshua Chang; Martí Lliteras, Pau; Euba, Begoña; Llobet, Enrique; Gil Puig, Carmen ; Bengoechea Alonso, José Antonio; Redfield, Rosemary J.; Liñares, Josefina (Public Library of Science, 2014) Artículo / ArtikuluaNontypable Haemophilus influenzae (NTHi) has emerged as an important opportunistic pathogen causing infection in adults suffering obstructive lung diseases. Existing evidence associates chronic infection by NTHi to the ... -
Complete genome sequence of Haemophilus influenzae strain 375 from the middle ear of a pediatric patient with otitis media
Mell, Joshua Chang; Sinha, Sunita; Balashov, Sergey; Viadas Martínez, Cristina ; Garmendia García, Juncal (American Society for Microbiology, 2014) Artículo / ArtikuluaOriginally isolated from a pediatric patient with otitis media, Haemophilus influenzae strain 375 (Hi375) has been extensively studied as a model system for intracellular invasion of airway epithelial cells and other ... -
Deciphering tissue-induced Klebsiella pneumoniae lipid A structure
Llobet, Enrique; Martínez Moliner, Verónica; Moranta, David; Dahlström, Käthe M.; Regueiro, Verónica; Tomás, Anna; Cano, Victoria; Pérez Gutiérrez, Camino; Frank, Christian G.; Garmendia García, Juncal (National Academy of Sciences, 2015) Artículo / ArtikuluaThe outcome of an infection depends on host recognition of the pathogen, hence leading to the activation of signaling pathways controlling defense responses. A long-held belief is that the modification of the lipid A ... -
Estudio de diversidad genotípica y del efecto del antibiótico azitromicina en la infeccion por el patógeno respiratorio Haemophilus influenzae no tipificable
Haemophilus infuenzae no tipificable (HiNT) es una bacteria Gram negativa que forma parte de la microbiota nasofaríngea humana y un patógeno oportunista. En pacientes con patologías como la Enfermedad Obstructiva Pulmonar ... -
Estudio de las bases moleculares de la infección respiratoria por el patógeno bacteriano Haemophilus influenzae: efecto de la auxotrofía metabólica e implementación de un nuevo modelo experimental preclínico
Este trabajo de tesis doctoral se centra en el estudio de las bases moleculares de la infección respiratoria por la bacteria Haemophilus influenzae, miembro del microbioma respiratorio humano y patógeno oportunista de ... -
Genome expression profiling-based identification and administration efficacy of host-directed antimicrobial drugs against respiratory infection by nontypeable Haemophilus influenzae
Euba, Begoña; Moleres Apilluelo, Javier ; Segura, Víctor; Viadas Martínez, Cristina ; Morey Sancho, Pau; Moranta, David; Leiva, José; Torres, Juan de; Bengoechea Alonso, José Antonio; Garmendia García, Juncal (American Society for Microbiology, 2015) Artículo / ArtikuluaTherapies that are safe, effective, and not vulnerable to developing resistance are highly desirable to counteract bacterial infections. Host-directed therapeutics is an antimicrobial approach alternative to conventional ... -
Inactivation of the Thymidylate synthase thyA in non-typeable Haemophilus influenzae modulates antibiotic resistance and has a strong impact on its interplay with the host airways
Rodríguez Arce, Irene ; Martí, Sara; Euba, Begoña; Fernández Calvet, Ariadna ; Moleres Apilluelo, Javier ; López López, Nahikari ; Barberán, Montserrat; Ramos Vivas, José; Tubau, Fe; Losa, Carmen; Ardanuy, Carmen; Leiva, José; Yuste, José E.; Garmendia García, Juncal (Frontiers Media, 2017) Artículo / ArtikuluaAntibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate ... -
Increased biofilm formation by nontypeable Haemophilus influenzae isolates from patients with invasive disease or otitis media versus strains recovered from cases of respiratory infections
Gil Puig, Carmen ; Domenech, Arnau; Garmendia García, Juncal; Langereis, Jeroen D.; Mayer, Pascal; Calatayud, Laura; Liñares, Josefina; Ardanuy, Carmen; Martí, Sara (American Society for Microbiology, 2014) Artículo / ArtikuluaBiofilm formation by nontypeable (NT) Haemophilus influenzae remains a controversial topic. Nevertheless, biofilm-like structures have been observed in the middle-ear mucosa of experimental chinchilla models of otitis media ... -
Klebsiella pneumoniae outer membrane protein A is required to prevent the activation of airway epithelial cells
March, Catalina; Moranta, David; Regueiro, Verónica; Llobet, Enrique; Tomás, Anna; Garmendia García, Juncal; Bengoechea Alonso, José Antonio (American Society for Biochemistry and Molecular Biology, 2011) Artículo / ArtikuluaOuter membrane protein A (OmpA) is a class of proteins highly conserved among the Enterobacteriaceae family and throughout evolution. Klebsiella pneumoniae is a capsulated Gram-negative pathogen. It is an important cause ... -
Mecanismos moleculares de adaptación del patógeno respiratorio Haemophilus influenzae y desarrollo de nuevos antimicrobianos
La tesis doctoral aborda tres aspectos de la interacción entre el patógeno oportunista colonizador Haemophilus influenzae no tipificable (HiNT) y el sistema respiratorio humano, considerando la regulación patoadaptativa ... -
Modeling Klebsiella pneumoniae pathogenesis by infection of the wax moth Galleria mellonella
Insua, José Luis; Llobet, Enrique; Moranta, David; Pérez Gutiérrez, Camino; Tomás, Anna; Garmendia García, Juncal; Bengoechea Alonso, José Antonio (American Society for Microbiology, 2013) Artículo / ArtikuluaThe implementation of infection models that approximate human disease is essential for understanding pathogenesis at the molecular level and for testing new therapies before they are entered into clinical stages. Insects ... -
Modulation of Haemophilus influenzae interaction with hydrophobic molecules by the VacJ/MlaA lipoprotein impacts strongly on its interplay with the airways
Fernández Calvet, Ariadna ; Rodríguez Arce, Irene ; Almagro Zabalza, Goizeder ; Moleres Apilluelo, Javier ; Caballero Coronado, Lucía; Garmendia García, Juncal (Springer, 2018) Artículo / ArtikuluaAirway infection by nontypeable Haemophilus influenzae (NTHi) associates to chronic obstructive pulmonary disease (COPD) exacerbation and asthma neutrophilic airway inflammation. Lipids are key inflammatory mediators in ... -
Nontypable haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates
Martí Lliteras, Pau; López Gómez, Antonio ; Mauro, Silvia; Hood, Derek W.; Viadas Martínez, Cristina ; Calatayud, Laura; Morey Sancho, Pau; Servin, Alain; Liñares, Josefina; Oliver, Antonio; Bengoechea Alonso, José Antonio; Garmendia García, Juncal (Public Library of Science, 2011) Artículo / ArtikuluaNon-typable Haemophilus influenzae (NTHi) is a Gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the ... -
Novel blaROB-1-bearing plasmid conferring resistance to β-lactams in Haemophilus parasuis isolates from healthy weaning pigs
Moleres Apilluelo, Javier ; Santos López, Alfonso; Lázaro, Isidro; Labairu, Javier; Prat, Cristina; Ardanuy, Carmen; González Zorn, Bruno; Aragon, Virginia; Garmendia García, Juncal (American Society for Microbiology, 2015) Artículo / ArtikuluaHaemophilus parasuis, the causative agent of Glässer’s disease, is one of the early colonizers of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with disease are fibrinous polyserositis ... -
Patho-adaptive evolution of Haemophilus spp. bacterial respiratory colonizing opportunistic pathogens
Esta tesis doctoral se ha centrado en tres aspectos de la pato-adaptación de dos especies bacterianas relacionadas filogenéticamente, que colonizan de forma asintomática y también son patógenos oportunistas en los sistemas ... -
Relationship between azithromycin susceptibility and administration efficacy for nontypeable Haemophilus influenzae respiratory infection
Euba, Begoña; Moleres Apilluelo, Javier ; Viadas Martínez, Cristina ; Barberán, Montserrat; Caballero Coronado, Lucía; Grilló Dolset, María Jesús; Bengoechea Alonso, José Antonio; Torres, Juan de; Liñares, Josefina; Leiva, José; Garmendia García, Juncal (American Society for Microbiology, 2015) Artículo / ArtikuluaNontypeable Haemophilus influenzae (NTHI) is an opportunistic pathogen that is an important cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). COPD is an inflammatory disease of the airways, ... -
Relative contribution of P5 and hap surface proteins to nontypable haemophilus influenzae interplay with the host upper and lower airways
Euba, Begoña; Moleres Apilluelo, Javier ; Viadas Martínez, Cristina ; Ruiz de los Mozos Aliaga, Igor ; Valle Turrillas, Jaione ; Bengoechea Alonso, José Antonio; Garmendia García, Juncal (Public Library of Science, 2015) Artículo / ArtikuluaNontypable Haemophilus influenzae (NTHi) is a major cause of opportunistic respiratory tract disease, and initiates infection by colonizing the nasopharynx. Bacterial surface proteins play determining roles in the ...